Liver Gene Transfer of Interkeukin-15 Constructs That Become Part of Circulating High Density Lipoproteins for Immunotherapy

Apolipoprotein A-I (Apo A-I) is a major component of high density lipoproteins (HDL) that transport cholesterol in circulation. We have constructed an expression plasmid encoding a chimeric molecule encompassing interleukin-15 (IL-15) and Apo A-I (pApo-hIL15) that was tested by hydrodynamic injectio...

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Hauptverfasser: Ochoa, Maria C., Fioravanti, Jessica, Duitman, Erwin H., Medina-Echeverz, Jose, Palazon, Asis, Arina, Ainhoa, Dubrot, Juan, Alfaro, Carlos, Morales-Kastresana, Aizea, Murillo, Oihana, Hervas-Stubbs, Sandra, Prieto, Jesus, Berraondo, Pedro, Melero, Ignacio
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science 2012
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3528770/
https://ncbi.nlm.nih.gov/pubmed/23285013
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0052370
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