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The Mutation V42M Distorts the Compact Packing of the Human Gamma-S-Crystallin Molecule, Resulting in Congenital Cataract

BACKGROUND: Human γS-crystallin is an important component of the human eye lens nucleus and cortex. The mutation V42M in the molecule causes severe congenital cataract in children. We compare the structure of the mutant protein with that of the wild type in order to understand how structural changes...

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Hlavní autoři: Vendra, Venkata Pulla Rao, Chandani, Sushil, Balasubramanian, Dorairajan
Médium: Artigo
Jazyk:Inglês
Vydáno: Public Library of Science 2012
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3528740/
https://ncbi.nlm.nih.gov/pubmed/23284690
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0051401
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