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Identification of Functionally Critical Residues in the Channel Domain of Inositol Trisphosphate Receptors

We have combined alanine mutagenesis and functional assays to identify amino acid residues in the channel domain that are critical for inositol 1,4,5-trisphosphate receptor (IP(3)R) channel function. The residues selected were highly conserved in all three IP(3)R isoforms and were located in the cyt...

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Main Authors: Bhanumathy, Cunnigaiper, da Fonseca, Paula C. A., Morris, Edward P., Joseph, Suresh K.
Formáid: Artigo
Teanga:Inglês
Foilsithe: American Society for Biochemistry and Molecular Biology 2012
Ábhair:
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3527953/
https://ncbi.nlm.nih.gov/pubmed/23086950
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.415786
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