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Identification of Functionally Critical Residues in the Channel Domain of Inositol Trisphosphate Receptors
We have combined alanine mutagenesis and functional assays to identify amino acid residues in the channel domain that are critical for inositol 1,4,5-trisphosphate receptor (IP(3)R) channel function. The residues selected were highly conserved in all three IP(3)R isoforms and were located in the cyt...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Biochemistry and Molecular Biology
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3527953/ https://ncbi.nlm.nih.gov/pubmed/23086950 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.415786 |
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