Calcium-dependent Conformational Changes in Inositol Trisphosphate Receptors

We have used limited trypsin digestion and reactivity with PEG-maleimides (MPEG) to study Ca(2+)-induced conformational changes of IP(3)Rs in their native membrane environment. We found that Ca(2+) decreased the formation of the 95-kDa C-terminal tryptic fragment when detected by an Ab directed at a...

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Autors principals: Anyatonwu, Georgia, Khan, M. Tariq, Schug, Zachary T., da Fonseca, Paula C. A., Morris, Edward P., Joseph, Suresh K.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Biochemistry and Molecular Biology 2010
Matèries:
Signal Transduction
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2915744/
https://ncbi.nlm.nih.gov/pubmed/20530483
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.123208
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