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Staurosporines Disrupt Phosphatidylserine Trafficking and Mislocalize Ras Proteins
Oncogenic mutant Ras is frequently expressed in human cancers, but no anti-Ras drugs have been developed. Since membrane association is essential for Ras biological activity, we developed a high content assay for inhibitors of Ras plasma membrane localization. We discovered that staurosporine and an...
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| Main Authors: | , , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Biochemistry and Molecular Biology
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3527944/ https://ncbi.nlm.nih.gov/pubmed/23124205 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.424457 |
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