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INHIBITION OF RHABDOMYOSARCOMA CELL AND TUMOR GROWTH BY TARGETING SPECIFICITY PROTEIN (Sp) TRANSCRIPTION FACTORS

Specificity protein (Sp) transcription factors Sp1, Sp3 and Sp4 are highly expressed in rhabdomyosarcoma (RMS) cells. In tissue arrays of RMS tumor cores from 71 patients, 80% of RMS patients expressed high levels of Sp1 protein, whereas low expression of Sp1 was detected in normal muscle tissue. Th...

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Autori principali: Chadalapaka, Gayathri, Jutooru, Indira, Sreevalsan, Sandeep, Pathi, Satya, Kim, Kyounghyun, Chen, Candy, Crose, Lisa, Linardic, Corinne, Safe, Stephen
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2012
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3527649/
https://ncbi.nlm.nih.gov/pubmed/22815231
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/ijc.27730
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