INHIBITION OF RHABDOMYOSARCOMA CELL AND TUMOR GROWTH BY TARGETING SPECIFICITY PROTEIN (Sp) TRANSCRIPTION FACTORS

Specificity protein (Sp) transcription factors Sp1, Sp3 and Sp4 are highly expressed in rhabdomyosarcoma (RMS) cells. In tissue arrays of RMS tumor cores from 71 patients, 80% of RMS patients expressed high levels of Sp1 protein, whereas low expression of Sp1 was detected in normal muscle tissue. Th...

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Main Authors: Chadalapaka, Gayathri, Jutooru, Indira, Sreevalsan, Sandeep, Pathi, Satya, Kim, Kyounghyun, Chen, Candy, Crose, Lisa, Linardic, Corinne, Safe, Stephen
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3527649/
https://ncbi.nlm.nih.gov/pubmed/22815231
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/ijc.27730
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