Imatinib and Nilotinib Inhibit Hematopoietic Progenitor Cell Growth, but Do Not Prevent Adhesion, Migration and Engraftment of Human Cord Blood CD34(+) Cells

BACKGROUND: The availability of tyrosine kinase inhibitors (TKIs) has considerably changed the management of Philadelphia chromosome positive leukemia. The BCR-ABL inhibitor imatinib is also known to inhibit the tyrosine kinase of the stem cell factor receptor, c-Kit. Nilotinib is 30 times more pote...

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Detalhes bibliográficos
Main Authors: Belle, Ludovic, Bruck, France, Foguenne, Jacques, Gothot, André, Beguin, Yves, Baron, Frédéric, Briquet, Alexandra
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2012
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3527577/
https://ncbi.nlm.nih.gov/pubmed/23285088
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0052564
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