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Ex vivo expansion of hematopoietic progenitor cells is associated with downregulation of α4 integrin- and CXCR4-mediated engraftment in NOD/SCID β(2)-microglobulin-null mice

BACKGROUND: Several studies indicate that ex vivo cytokine-supported expansion induces defective hematopoietic stem cell engraftment. We investigated the role of α4 integrin, α5 integrin and CXCR4 in engraftment of unmanipulated and cytokine-treated human cord blood CD34(+) cells. DESIGN AND METHODS...

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Detaylı Bibliyografya
Asıl Yazarlar: Foguenne, Jacques, Di Stefano, Ivano, Giet, Olivier, Beguin, Yves, Gothot, André
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Ferrata Storti Foundation 2009
Konular:
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC2635392/
https://ncbi.nlm.nih.gov/pubmed/19144663
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3324/haematol.13206
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