Phosphonopeptides as Antibacterial Agents: Mechanism of Action of Alaphosphin

The novel antibacterial peptide mimetic alaphosphin (l-alanyl-l-1-aminoethylphosphonic acid) selectively inhibited peptidoglycan biosynthesis in both gram-negative and gram-positive bacteria. It induced accumulation of uridine diphosphate-N-acetyl-muramyl-tripeptide in gram-positive organisms and si...

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Pubblicato in:	Antimicrob Agents Chemother
Autori principali:	Atherton, Frank R., Hall, Michael J., Hassall, Cedric H., Lambert, Robert W., Lloyd, William J., Ringrose, Peter S.
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	American Society for Microbiology (ASM) 1979
Soggetti:	Biosynthesis; Chemistry; Mechanisms of Action and Resistance
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC352740/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/525987/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/aac.15.5.696
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