Transport Mechanisms and Their Pathology-Induced Regulation Govern Tyrosine Kinase Inhibitor Delivery in Rheumatoid Arthritis

BACKGROUND: Tyrosine kinase inhibitors (TKIs) are effective in treating malignant disorders and were lately suggested to have an impact on non-malignant diseases. However, in some inflammatory conditions like rheumatoid arthritis (RA) the in vivo effect seemed to be moderate. As most TKIs are taken...

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Detalhes bibliográficos
Main Authors: Schmidt-Lauber, Christian, Harrach, Saliha, Pap, Thomas, Fischer, Meike, Victor, Marion, Heitzmann, Marianne, Hansen, Uwe, Fobker, Manfred, Brand, Stefan-Martin, Sindic, Aleksandra, Pavenstädt, Hermann, Edemir, Bayram, Schlatter, Eberhard, Bertrand, Jessica, Ciarimboli, Giuliano
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2012
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3527388/
https://ncbi.nlm.nih.gov/pubmed/23284953
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0052247
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