Effect of Acycloguanosine Treatment on Acute and Latent Herpes Simplex Infections in Mice

Systemic treatment of mice with the nucleoside analog 9-(2-hydroxyethoxymethyl)guanine (acycloguanosine [aciclovir]) was found to be highly effective against acute type 1 herpes simplex virus infection of the pinna. The drug ablated clinical signs and reduced virus replication both in tissue local t...

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Bibliographic Details

Published in:	Antimicrob Agents Chemother
Main Authors:	Field, Hugh J., Bell, Susanne E., Elion, Gertrude B., Nash, Anthony A., Wildy, Peter
Format:	Artigo
Language:	Inglês
Published:	American Society for Microbiology (ASM) 1979
Subjects:	Pharmacology and Therapeutics
Online Access:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC352710/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/464587/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/aac.15.4.554
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