Attenuated vasodilatation in lambs with endogenous and exogenous activation of cGMP signaling: Role of protein kinase G nitration

Pulmonary vasodilation is mediated through the activation of protein kinase G (PKG) via a signaling pathway involving nitric oxide (NO), natriuretic peptides (NP), and cyclic guanosine monophosphate (cGMP). In pulmonary hypertension secondary to congenital heart disease, this pathway is endogenously...

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Hauptverfasser: Aggarwal, Saurabh, Gross, Christine M., Kumar, Sanjiv, Datar, Sanjeev, Oishi, Peter, Kalka, Gokhan, Schreiber, Christian, Fratz, Sohrab, Fineman, Jeffrey R., Black, Stephen M.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2011
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3527072/
https://ncbi.nlm.nih.gov/pubmed/21351102
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/jcp.22692
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