Successful attenuation of humoral immunity to viral capsid and transgenic protein following AAV mediated gene transfer with a non-depleting CD4 antibody and cyclosporine

The ability of transient immunosuppression with a combination of a nondepleting anti-CD4 (NDCD4) antibody and Cyclosporine (CyA) to abrogate immune reactivity to both adeno-associated virus vector (AAV) and its transgene product was evaluated. This combination of immunosuppressants resulted in a 20-...

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Autori principali: McIntosh, Jenny, Cochrane, Melanie, Cobbold, Stephen, Waldmann, Herman, Davidoff, Andrew M., Nathwani, Amit C.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2011
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3526978/
https://ncbi.nlm.nih.gov/pubmed/21716299
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/gt.2011.64
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