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A colitis locus on chromosome 2 impacting the severity of early-onset disease in mice deficient in GPX1 and GPX2
BACKGROUND: Genetic background has a profound effect on inflammatory bowel disease. The Gpx1 and Gpx2 double knockout (GPX1/2-DKO) mice on a mixed C57BL/6 (B6) and 129S1/SvimJ (129) background had spontaneous ileocolitis. The DKO mice on a B6 background had mild ileocolitis. We characterized the 129...
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| Hauptverfasser: | , , , , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2010
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3526817/ https://ncbi.nlm.nih.gov/pubmed/20872835 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/ibd.21479 |
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