Deficiency in Duox2 activity alleviates ileitis in GPx1- and GPx2-knockout mice without affecting apoptosis incidence in the crypt epithelium

Mice deficient in glutathione peroxidase (GPx)-1 and -2 (GPx1(-/-)GPx2(-/-) double knockout or DKO mice) develop very-early-onset (VEO) ileocolitis, suggesting that lack of defense against reactive oxygen species (ROS) renders susceptibility to intestinal inflammation. Two members of ROS-generating...

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Publicat a:Redox Biol
Autors principals: Chu, Fong-Fong, Esworthy, R. Steven, Doroshow, James H., Grasberger, Helmut, Donko, Agnes, Leto, Thomas L., Gao, Qiang, Shen, Binghui
Format: Artigo
Idioma:Inglês
Publicat: Elsevier 2016
Matèries:
Research Paper
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5148781/
https://ncbi.nlm.nih.gov/pubmed/27930931
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.redox.2016.11.001
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