Hypothyroidism-associated missense mutation impairs NADPH oxidase activity and intracellular trafficking of Duox2

In the thyroid gland Duox2-derived H(2)O(2) is essential for thyroid hormone biosynthesis. Several patients were identified with partial or severe iodide organification defects caused by mutations in genes for Duox2 or its maturation factor, DuoxA2. A Duox2-deficient (Duox2(thyd)) mouse model enable...

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Bibliografski detalji
Glavni autori: Donkó, Ágnes, Morand, Stanislas, Korzeniowska, Agnieszka, Boudreau, Howard E., Zana, Melinda, Hunyady, László, Geiszt, Miklós, Leto, Thomas L.
Format: Artigo
Jezik:Inglês
Izdano: 2014
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Article
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4111973/
https://ncbi.nlm.nih.gov/pubmed/24853759
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.freeradbiomed.2014.05.006
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