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Hypothyroidism-associated missense mutation impairs NADPH oxidase activity and intracellular trafficking of Duox2
In the thyroid gland Duox2-derived H(2)O(2) is essential for thyroid hormone biosynthesis. Several patients were identified with partial or severe iodide organification defects caused by mutations in genes for Duox2 or its maturation factor, DuoxA2. A Duox2-deficient (Duox2(thyd)) mouse model enable...
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| Главные авторы: | , , , , , , , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
2014
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4111973/ https://ncbi.nlm.nih.gov/pubmed/24853759 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.freeradbiomed.2014.05.006 |
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