Hypothyroidism-associated missense mutation impairs NADPH oxidase activity and intracellular trafficking of Duox2

In the thyroid gland Duox2-derived H(2)O(2) is essential for thyroid hormone biosynthesis. Several patients were identified with partial or severe iodide organification defects caused by mutations in genes for Duox2 or its maturation factor, DuoxA2. A Duox2-deficient (Duox2(thyd)) mouse model enable...

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Библиографические подробности
Главные авторы: Donkó, Ágnes, Morand, Stanislas, Korzeniowska, Agnieszka, Boudreau, Howard E., Zana, Melinda, Hunyady, László, Geiszt, Miklós, Leto, Thomas L.
Формат: Artigo
Язык:Inglês
Опубликовано: 2014
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Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC4111973/
https://ncbi.nlm.nih.gov/pubmed/24853759
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.freeradbiomed.2014.05.006
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