Mineralocorticoid and glucocorticoid receptors differentially regulate NF-kappaB activity and pro-inflammatory cytokine production in murine BV-2 microglial cells

BACKGROUND: Microglia, the resident macrophage-like cells in the brain, regulate innate immune responses in the CNS to protect neurons. However, excessive activation of microglia contributes to neurodegenerative diseases. Corticosteroids are potent modulators of inflammation and mediate their effect...

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Main Authors: Chantong, Boonrat, Kratschmar, Denise V, Nashev, Lyubomir G, Balazs, Zoltan, Odermatt, Alex
Formato: Artigo
Idioma:Inglês
Publicado: BioMed Central 2012
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Research
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3526453/
https://ncbi.nlm.nih.gov/pubmed/23190711
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1742-2094-9-260
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