Inhibition of metabotropic glutamate receptor 5 induces cellular stress through pertussis toxin-sensitive G(i)-proteins in murine BV-2 microglia cells

BACKGROUND: Activation of metabotropic glutamate receptor 5 (mGluR5) by (RS)-2-chloro-5-hydroxyphenylglycine (CHPG) was shown to suppress microglia activation and decrease the release of associated pro-inflammatory mediators. In contrast, the consequences of mGluR5 inhibition are less well understoo...

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Veröffentlicht in:J Neuroinflammation
Hauptverfasser: Chantong, Boonrat, Kratschmar, Denise V, Lister, Adam, Odermatt, Alex
Format: Artigo
Sprache:Inglês
Veröffentlicht: BioMed Central 2014
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Research
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4240888/
https://ncbi.nlm.nih.gov/pubmed/25407356
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12974-014-0190-7
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