Wheat amylase trypsin inhibitors drive intestinal inflammation via activation of toll-like receptor 4

Ingestion of wheat, barley, or rye triggers small intestinal inflammation in patients with celiac disease. Specifically, the storage proteins of these cereals (gluten) elicit an adaptive Th1-mediated immune response in individuals carrying HLA-DQ2 or HLA-DQ8 as major genetic predisposition. This wel...

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Main Authors: Junker, Yvonne, Zeissig, Sebastian, Kim, Seong-Jun, Barisani, Donatella, Wieser, Herbert, Leffler, Daniel A., Zevallos, Victor, Libermann, Towia A., Dillon, Simon, Freitag, Tobias L., Kelly, Ciaran P., Schuppan, Detlef
Format: Artigo
Sprog:Inglês
Udgivet: The Rockefeller University Press 2012
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3526354/
https://ncbi.nlm.nih.gov/pubmed/23209313
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20102660
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