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Evolutionary transitions to new DNA methyltransferases through target site expansion and shrinkage
DNA-binding and modifying proteins show high specificity but also exhibit a certain level of promiscuity. Such latent promiscuous activities comprise the starting points for new protein functions, but this hypothesis presents a paradox: a new activity can only evolve if it already exists. How then,...
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
Oxford University Press
2012
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3526282/ https://ncbi.nlm.nih.gov/pubmed/23074188 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gks944 |
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