SPOC1 modulates DNA repair by regulating key determinants of chromatin compaction and DNA damage response

Survival time-associated plant homeodomain (PHD) finger protein in Ovarian Cancer 1 (SPOC1, also known as PHF13) is known to modulate chromatin structure and is essential for testicular stem-cell differentiation. Here we show that SPOC1 is recruited to DNA double-strand breaks (DSBs) in an ATM-depen...

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Autori principali: Mund, Andreas, Schubert, Tobias, Staege, Hannah, Kinkley, Sarah, Reumann, Kerstin, Kriegs, Malte, Fritsch, Lauriane, Battisti, Valentine, Ait-Si-Ali, Slimane, Hoffbeck, Anne-Sophie, Soutoglou, Evi, Will, Hans
Natura: Artigo
Lingua:Inglês
Pubblicazione: Oxford University Press 2012
Soggetti:
Genome Integrity, Repair and Replication
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3526275/
https://ncbi.nlm.nih.gov/pubmed/23034801
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gks868
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