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Kinase inhibitors arrest neurodegeneration in cell and C. elegans models of LRRK2 toxicity

Mutations in leucine-rich repeat kinase 2 (LRRK2) are the most frequent known cause of late-onset Parkinson's disease (PD). To explore the therapeutic potential of small molecules targeting the LRRK2 kinase domain, we characterized two LRRK2 kinase inhibitors, TTT-3002 and LRRK2-IN1, for their...

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書誌詳細
主要な著者: Yao, Chen, Johnson, William M., Gao, Yue, Wang, Wen, Zhang, Jinwei, Deak, Maria, Alessi, Dario R., Zhu, Xiongwei, Mieyal, John J., Roder, Hanno, Wilson-Delfosse, Amy L., Chen, Shu G.
フォーマット: Artigo
言語:Inglês
出版事項: Oxford University Press 2013
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC3526163/
https://ncbi.nlm.nih.gov/pubmed/23065705
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/dds431
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