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22q11 Gene dosage establishes an adaptive range for sonic hedgehog and retinoic acid signaling during early development

We asked whether key morphogenetic signaling pathways interact with 22q11 gene dosage to modulate the severity of cranial or cardiac anomalies in DiGeorge/22q1 deletion syndrome (22q11DS). Sonic hedgehog (Shh) and retinoic acid (RA) signaling is altered in the brain and heart—clinically significant...

पूर्ण विवरण

में बचाया:
ग्रंथसूची विवरण
मुख्य लेखकों: Maynard, Thomas M., Gopalakrishna, Deepak, Meechan, Daniel W., Paronett, Elizabeth M., Newbern, Jason M., LaMantia, Anthony-Samuel
स्वरूप: Artigo
भाषा:Inglês
प्रकाशित: Oxford University Press 2013
विषय:
ऑनलाइन पहुंच:https://ncbi.nlm.nih.gov/pmc/articles/PMC3526161/
https://ncbi.nlm.nih.gov/pubmed/23077214
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/dds429
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