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22q11 Gene dosage establishes an adaptive range for sonic hedgehog and retinoic acid signaling during early development
We asked whether key morphogenetic signaling pathways interact with 22q11 gene dosage to modulate the severity of cranial or cardiac anomalies in DiGeorge/22q1 deletion syndrome (22q11DS). Sonic hedgehog (Shh) and retinoic acid (RA) signaling is altered in the brain and heart—clinically significant...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Oxford University Press
2013
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3526161/ https://ncbi.nlm.nih.gov/pubmed/23077214 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/dds429 |
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