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The Birt–Hogg–Dubé tumor suppressor Folliculin negatively regulates ribosomal RNA synthesis
Birt–Hogg–Dubé syndrome (BHD) is a human cancer disorder caused by mutations in the tumor suppressor gene Folliculin (FLCN) with unknown biological functions. Here, we show that the Drosophila homolog of FLCN, dFLCN (a.k.a. dBHD) localizes to the nucleolus and physically interacts with the 19S prote...
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| Main Authors: | , , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Oxford University Press
2013
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3526160/ https://ncbi.nlm.nih.gov/pubmed/23077212 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/dds428 |
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