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A sequence-based approach demonstrates that balancing selection in classical human leukocyte antigen (HLA) loci is asymmetric

Balancing selection has maintained human leukocyte antigen (HLA) allele diversity, but it is unclear whether this selection is symmetric (all heterozygotes are comparable and all homozygotes are comparable in terms of fitness) or asymmetric (distinct heterozygote genotypes display greater fitness th...

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Bibliografiske detaljer
Main Authors: Bronson, Paola G., Mack, Steven J., Erlich, Henry A., Slatkin, Montgomery
Format: Artigo
Sprog:Inglês
Udgivet: Oxford University Press 2013
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3526157/
https://ncbi.nlm.nih.gov/pubmed/23065702
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/dds424
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