NAADP Activates Two-Pore Channels on T Cell Cytolytic Granules to Stimulate Exocytosis and Killing

A cytotoxic T lymphocyte (CTL) kills an infected or tumorigenic cell by Ca(2+)-dependent exocytosis of cytolytic granules at the immunological synapse formed between the two cells. Although inositol 1,4,5-trisphosphate (IP(3))-mediated Ca(2+) release from the endoplasmic reticulum activates the stor...

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Main Authors: Davis, Lianne C., Morgan, Anthony J., Chen, Ji-Li, Snead, Charlotte M., Bloor-Young, Duncan, Shenderov, Eugene, Stanton-Humphreys, Megan N., Conway, Stuart J., Churchill, Grant C., Parrington, John, Cerundolo, Vincenzo, Galione, Antony
Formato: Artigo
Idioma:Inglês
Publicado em: Cell Press 2012
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3525857/
https://ncbi.nlm.nih.gov/pubmed/23177477
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cub.2012.10.035
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