טוען...
Regulatory mechanisms of nucleic acid-mediated innate immune responses in the tumor microenvironment
We identified novel mechanisms whereby TIM-3 suppresses innate immunity as induced by nucleic acids. Interaction of TIM-3 with HMGB1 inhibits the recruitment of nucleic acids to the endosomal compartment of dendritic cells, impairing the transduction of innate immune signals. Thus, TIM-3 is an effec...
שמור ב:
| מחבר ראשי: | |
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| פורמט: | Artigo |
| שפה: | Inglês |
| יצא לאור: |
Landes Bioscience
2012
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| נושאים: | |
| גישה מקוונת: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3525627/ https://ncbi.nlm.nih.gov/pubmed/23264918 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/onci.21681 |
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