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Targeted Multiplex Imaging Mass Spectrometry with Single Chain Fragment Variable (scfv) Recombinant Antibodies

Recombinant scfv antibodies specific for CYP1A1 and CYP1B1 P450 enzymes were combined with targeted imaging mass spectrometry to simultaneously detect the P450 enzymes present in archived, paraffin-embedded, human breast cancer tissue sections. By using CYP1A1 and CYP1B1 specific scfv, each coupled...

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Main Authors: Thiery, Gwendoline, Mernaugh, Ray L., Yan, Heping, Spraggins, Jeffrey M., Yang, Junhai, Parl, Fritz F., Caprioli, Richard M.
Formato: Artigo
Idioma:Inglês
Publicado: 2012
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3525520/
https://ncbi.nlm.nih.gov/pubmed/22869296
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s13361-012-0423-x
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