Microbial Transformations of Natural Antitumor Agents: O-Demethylation of Vindoline by Sepedonium chrysospermum

Vindoline (1a) was transformed to O-demethylvindoline (1b) by Sepedonium chrysospermum ATCC 13378 in 33% yield. Thin-layer and high-pressure liquid chromatographic methods distinguished 1b from previously reported microbial metabolites of vindoline. The structural proof of 1b was based on its mass s...

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Bibliografische gegevens
Hoofdauteurs: Wu, Geng-Shuen, Nabih, Thomas, Youel, Leisa, Peczynska-Czoch, Wanda, Rosazza, John P.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 1978
Onderwerpen:
Biosynthesis; Chemistry; Mechanisms of Action and Resistance
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC352513/
https://ncbi.nlm.nih.gov/pubmed/568911
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