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Microbial transformations of natural antitumor agents: oxidation of lapachol by Penicillium notatum.

The naphthoquinone lapachol (1) is readily metabolized by several fungi and streptomycetes. Preparative-scale fermentations with Penicillium notatum (UI 1602) provided a major polar metabolite (4), which was isolated and identified as an intermediate of the Hooker oxidation. The metabolite was synth...

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Bibliografski detalji
Izdano u:Appl Environ Microbiol
Glavni autori: Otten, S, Rosazza, J P
Format: Artigo
Jezik:Inglês
Izdano: American Society for Microbiology (ASM) 1978
Teme:
Online pristup:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC242878/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/637549/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/aem.35.3.554-557.1978
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