Microbial transformations of natural antitumor agents: oxidation of lapachol by Penicillium notatum.
The naphthoquinone lapachol (1) is readily metabolized by several fungi and streptomycetes. Preparative-scale fermentations with Penicillium notatum (UI 1602) provided a major polar metabolite (4), which was isolated and identified as an intermediate of the Hooker oxidation. The metabolite was synth...
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| Publicado no: | Appl Environ Microbiol |
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| Principais autores: | , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Microbiology (ASM)
1978
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC242878/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/637549/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/aem.35.3.554-557.1978 |
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