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Microbial Transformations of Natural Antitumor Agents: O-Demethylation of Vindoline by Sepedonium chrysospermum

Vindoline (1a) was transformed to O-demethylvindoline (1b) by Sepedonium chrysospermum ATCC 13378 in 33% yield. Thin-layer and high-pressure liquid chromatographic methods distinguished 1b from previously reported microbial metabolites of vindoline. The structural proof of 1b was based on its mass s...

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Détails bibliographiques
Publié dans:Antimicrob Agents Chemother
Auteurs principaux: Wu, Geng-Shuen, Nabih, Thomas, Youel, Leisa, Peczynska-Czoch, Wanda, Rosazza, John P.
Format: Artigo
Langue:Inglês
Publié: American Society for Microbiology (ASM) 1978
Sujets:
Accès en ligne:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC352513/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/568911/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/aac.14.4.601
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