Enhancement of the Immunogenicity and Protective Efficacy of a Mucosal Influenza Subunit Vaccine by the Saponin Adjuvant GPI-0100

Identification of safe and effective adjuvants remains an urgent need for the development of inactivated influenza vaccines for mucosal administration. Here, we used a murine challenge model to evaluate the adjuvant activity of GPI-0100, a saponin-derived adjuvant, on influenza subunit vaccine admin...

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Autores principales: Liu, Heng, Patil, Harshad P., de Vries-Idema, Jacqueline, Wilschut, Jan, Huckriede, Anke
Formato: Artigo
Lenguaje:Inglês
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3524133/
https://ncbi.nlm.nih.gov/pubmed/23284901
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0052135
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