Gene, pathway and network frameworks to identify epistatic interactions of single nucleotide polymorphisms derived from GWAS data

BACKGROUND: Interactions among genomic loci (also known as epistasis) have been suggested as one of the potential sources of missing heritability in single locus analysis of genome-wide association studies (GWAS). The computational burden of searching for interactions is compounded by the extremely...

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Detalhes bibliográficos
Main Authors: Liu, Yu, Maxwell, Sean, Feng, Tao, Zhu, Xiaofeng, Elston, Robert C, Koyutürk, Mehmet, Chance, Mark R
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2012
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3524014/
https://ncbi.nlm.nih.gov/pubmed/23281810
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1752-0509-6-S3-S15
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