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Effect of N′-Methylnicotinamide on the Renal Accumulation and Reabsorption of Gentamicin in Rats
N′-methylnicotinamide, a substrate of the organic base transport system, reduced renal accumulation of [(14)C]gentamicin in rats by 15% and increased clearance by 25%, suggesting that gentamicin is not secreted by this mechanism.
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| Main Authors: | , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
1978
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC352352/ https://ncbi.nlm.nih.gov/pubmed/149514 |
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