Heterologous Prime/Boost Immunization with p53-based Vaccines Combined with Toll-Like Receptor Stimulation Enhances Tumor Regression

The p53 gene product is overexpressed in ~50% of cancers, making it an ideal target for cancer immunotherapy. We previously demonstrated that a modified vaccinia Ankara (MVA) vaccine expressing human p53 (MVA-p53) was moderately active when given as a homologous prime/boost in a human p53 knock in (...

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Bibliografiske detaljer
Main Authors: Ishizaki, Hidenobu, Song, Guang-Yun, Srivastava, Tumul, Carroll, Kyla Driscoll, Shahabi, Vafa, Manuel, Edwin R., Diamond, Don J., Ellenhorn, Joshua D.I.
Format: Artigo
Sprog:Inglês
Udgivet: 2010
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3523364/
https://ncbi.nlm.nih.gov/pubmed/20551836
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/CJI.0b013e3181e032c6
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