Proinsulin Slows Retinal Degeneration and Vision Loss in the P23H Rat Model of Retinitis Pigmentosa

Proinsulin has been characterized as a neuroprotective molecule. In this work we assess the therapeutic potential of proinsulin on photoreceptor degeneration, synaptic connectivity, and functional activity of the retina in the transgenic P23H rat, an animal model of autosomal dominant retinitis pigm...

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Autors principals: Fernández-Sánchez, Laura, Lax, Pedro, Isiegas, Carolina, Ayuso, Eduard, Ruiz, José M., de la Villa, Pedro, Bosch, Fatima, de la Rosa, Enrique J., Cuenca, Nicolás
Format: Artigo
Idioma:Inglês
Publicat: Mary Ann Liebert, Inc. 2012
Matèries:
Research Articles
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3523255/
https://ncbi.nlm.nih.gov/pubmed/23017108
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/hum.2012.067
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