Proinsulin Slows Retinal Degeneration and Vision Loss in the P23H Rat Model of Retinitis Pigmentosa

Proinsulin has been characterized as a neuroprotective molecule. In this work we assess the therapeutic potential of proinsulin on photoreceptor degeneration, synaptic connectivity, and functional activity of the retina in the transgenic P23H rat, an animal model of autosomal dominant retinitis pigm...

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Detalhes bibliográficos
Main Authors: Fernández-Sánchez, Laura, Lax, Pedro, Isiegas, Carolina, Ayuso, Eduard, Ruiz, José M., de la Villa, Pedro, Bosch, Fatima, de la Rosa, Enrique J., Cuenca, Nicolás
Formato: Artigo
Idioma:Inglês
Publicado em: Mary Ann Liebert, Inc. 2012
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3523255/
https://ncbi.nlm.nih.gov/pubmed/23017108
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/hum.2012.067
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