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Irreversible Effects of Serum Proteins on Beta-Lactam Antibiotics

The chromogenic cephalosporin nitrocefin (87/312) demonstrates rapid and visible instability to serum from many species. This phenomenon was distinct from serum binding, being significantly slower. Destruction of another cephalosporin, 10485, by serum appeared to account for some anomalous results d...

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Bibliographic Details
Published in:Antimicrob Agents Chemother
Main Author: O'Callaghan, Cynthia H.
Format: Artigo
Language:Inglês
Published: American Society for Microbiology (ASM) 1978
Subjects:
Online Access:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC352300/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/27139/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/aac.13.4.628
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