Inhaled LPS challenges in smokers: a study of pulmonary and systemic effects

AIMS: Lipopolysaccharide (LPS) is a TLR4 agonist which activates NFκB dependent cytokine production. We investigated LPS inhalation in healthy smokers as a model of COPD bacterial exacerbations. We studied safety, reproducibility, the translocation of the NFκB subunit p65 in sputum cells and changes...

Descripción completa

Guardado en:
Detalles Bibliográficos
Autores principales: Aul, Raminder, Armstrong, Jane, Duvoix, Annelyse, Lomas, David, Hayes, Brian, Miller, Bruce E, Jagger, Chris, Singh, Dave
Formato: Artigo
Lenguaje:Inglês
Publicado: Blackwell Science Inc 2012
Materias:
Methods in Clinical Pharmacology
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3522816/
https://ncbi.nlm.nih.gov/pubmed/22469312
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1365-2125.2012.04287.x
Etiquetas: Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!

Ejemplares similares