Inhaled LPS challenges in smokers: a study of pulmonary and systemic effects

AIMS: Lipopolysaccharide (LPS) is a TLR4 agonist which activates NFκB dependent cytokine production. We investigated LPS inhalation in healthy smokers as a model of COPD bacterial exacerbations. We studied safety, reproducibility, the translocation of the NFκB subunit p65 in sputum cells and changes...

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Detalhes bibliográficos
Main Authors: Aul, Raminder, Armstrong, Jane, Duvoix, Annelyse, Lomas, David, Hayes, Brian, Miller, Bruce E, Jagger, Chris, Singh, Dave
Formato: Artigo
Idioma:Inglês
Publicado em: Blackwell Science Inc 2012
Assuntos:
Methods in Clinical Pharmacology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3522816/
https://ncbi.nlm.nih.gov/pubmed/22469312
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1365-2125.2012.04287.x
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