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Serum and urine bone resorption markers and pharmacokinetics of the cathepsin K inhibitor ONO-5334 after ascending single doses in post menopausal women

AIMS: To investigate the safety, pharmacokinetics and pharmacodynamics of the new cathepsin K inhibitor, ONO-5334. METHODS: A double-blind, placebo-controlled, randomized studywas carried out in 52 healthy post menopausal females. Single ascending doses of ONO-5334 (3–600 mg) were evaluated in six c...

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書誌詳細
主要な著者: Nagase, Shinichi, Hashimoto, Yoshitaka, Small, Maria, Ohyama, Michiyo, Kuwayama, Tomohiro, Deacon, Steve
フォーマット: Artigo
言語:Inglês
出版事項: Blackwell Science Inc 2012
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC3522809/
https://ncbi.nlm.nih.gov/pubmed/22533981
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1365-2125.2012.04307.x
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