Effects of the Cathepsin K Inhibitor ONO-5334 and Concomitant Use of ONO-5334 with Methotrexate on Collagen-Induced Arthritis in Cynomolgus Monkeys

We examined whether the cathepsin K inhibitor, ONO-5334, administered alone or in combination with methotrexate (MTX), could ameliorate joint destruction evoked by collagen-induced arthritis (CIA) in female cynomolgus monkeys. CIA was induced by immunizing with bovine type II collagen. ONO-5334 (30...

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Detalhes bibliográficos
Publicado no:Int J Rheumatol
Main Authors: Yamada, Hiroyuki, Mori, Hiroshi, Nakanishi, Yasutomo, Nishikawa, Satoshi, Hashimoto, Yasuaki, Ochi, Yasuo, Tanaka, Makoto, Kawabata, Kazuhito
Formato: Artigo
Idioma:Inglês
Publicado em: Hindawi 2019
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6397998/
https://ncbi.nlm.nih.gov/pubmed/30906325
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2019/5710340
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