Serum and urine bone resorption markers and pharmacokinetics of the cathepsin K inhibitor ONO-5334 after ascending single doses in post menopausal women

AIMS: To investigate the safety, pharmacokinetics and pharmacodynamics of the new cathepsin K inhibitor, ONO-5334. METHODS: A double-blind, placebo-controlled, randomized studywas carried out in 52 healthy post menopausal females. Single ascending doses of ONO-5334 (3–600 mg) were evaluated in six c...

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Detalhes bibliográficos
Main Authors: Nagase, Shinichi, Hashimoto, Yoshitaka, Small, Maria, Ohyama, Michiyo, Kuwayama, Tomohiro, Deacon, Steve
Formato: Artigo
Idioma:Inglês
Publicado em: Blackwell Science Inc 2012
Assuntos:
Pharmacodynamics
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3522809/
https://ncbi.nlm.nih.gov/pubmed/22533981
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1365-2125.2012.04307.x
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