Reduced Hepatic Stellate Cell Expression of KLF6 Tumor Suppressor Isoforms Amplifies Fibrosis During Acute and Chronic Rodent Liver Injury

Kruppel like factor 6 (KLF6), a zinc finger transcription factor and tumor suppressor, is induced as an immediate-early gene during hepatic stellate cell (HSC) activation. The paradoxical induction of a tumor suppressor in HSCs during proliferation led us to explore the biology of wild type KLF6 (KL...

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Hlavní autoři: Ghiassi-Nejad, Zahra, Hernandez-Gea, Virginia, Woodrell, Christopher, Lang, Ursula E., Dumic, Katja, Kwong, Allison, Friedman, Scott L.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2012
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3522757/
https://ncbi.nlm.nih.gov/pubmed/22961688
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/hep.26056
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