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DIRECT LOADING OF PURIFIED ENDOGENOUS INHIBITOR INTO THE CYTOPLASM OF PATCHED CARDIOMYOCYTES BLOCKS THE ION-CURRENTS AND CALCIUM TRANSPORT THROUGH THE NCX1 PROTEIN
The Na(+)/Ca(2+) exchanger in mammalian heart muscle (NCX1) is the central transporter protein that regulates Ca(2+) extrusion from the heart cell. However, the functional biochemistry and physiology of NCX1 has been severely hampered by the absence of any specific high-affinity inhibitor. Here we d...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
2008
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3522518/ https://ncbi.nlm.nih.gov/pubmed/18507397 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi8004279 |
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