A Single Residue within the V5 Region of HIV-1 Envelope Facilitates Viral Escape from the Broadly Neutralizing Monoclonal Antibody VRC01

VRC01, a broadly neutralizing monoclonal antibody, is capable of neutralizing a diverse array of HIV-1 isolates by mimicking CD4 binding with the envelope glycoprotein gp120. Nonetheless, resistant strains have been identified. Here, we examined two genetically related and two unrelated envelope clo...

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Bibliographische Detailangaben
Hauptverfasser: Guo, Dongxing, Shi, Xuanling, Arledge, Kelly C., Song, Dingka, Jiang, Liwei, Fu, Lili, Gong, Xinqi, Zhang, Senyan, Wang, Xinquan, Zhang, Linqi
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Biochemistry and Molecular Biology 2012
Schlagworte:
Microbiology
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3522310/
https://ncbi.nlm.nih.gov/pubmed/23100255
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.399402
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