The Phosphocholine-binding Pocket on C-reactive Protein Is Necessary for Initial Protection of Mice against Pneumococcal Infection

Human C-reactive protein (CRP) protects mice from lethal Streptococcus pneumoniae infection when injected into mice within the range of 6 h before to 2 h after the administration of pneumococci. Because CRP binds to phosphocholine-containing substances and subsequently activates the complement syste...

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Detalhes bibliográficos
Main Authors: Gang, Toh B., Hammond, David J., Singh, Sanjay K., Ferguson, Donald A., Mishra, Vinod K., Agrawal, Alok
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2012
Assuntos:
Immunology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3522306/
https://ncbi.nlm.nih.gov/pubmed/23139417
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.427310
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