The Exosome Secretory Pathway Transports Amyloid Precursor Protein Carboxyl-terminal Fragments from the Cell into the Brain Extracellular Space

In vitro studies have shown that neuronal cell cultures secrete exosomes containing amyloid-β precursor protein (APP) and the APP-processing products, C-terminal fragments (CTFs) and amyloid-β (Aβ). We investigated the secretion of full-length APP (flAPP) and APP CTFs via the exosome secretory pathw...

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Hlavní autoři: Perez-Gonzalez, Rocio, Gauthier, Sebastien A., Kumar, Asok, Levy, Efrat
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Biochemistry and Molecular Biology 2012
Témata:
Neurobiology
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3522305/
https://ncbi.nlm.nih.gov/pubmed/23129776
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.404467
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